Monday, September 8, 2008

Goodbye Depakote, It's Been Nice (Not Really)

I couldn't come up with anything better than to reference an old Supertramp song. Obscure, yes.

Less than 2 weeks after starting Depakote, we took Mira off it. We noticed a drastic change in her mood soon after starting it. She became increasingly irritable all of last week, which escalated to her screaming Friday night and turning purple she was getting so upset. She had a lot of trouble decompressing at night and did a lot of screaming all week. It did nothing for her seizures so we decided Friday was her last day on it. Today she is pretty much back to her old self.

We had a similar episode when she tried Felbatol in early 2007, only we took her off of that after only a few days. That was really awful for her. We haven't seen such a poor reaction to a medication since Felbatol, thankfully, but Depakote was a good contender for worst meds.

We put a call in to neurology to see what her neuro suggests. Frankly, there isn't much left that she hasn't tried, other than Neurontin (Gabapentin), Zarontin (Ethosuximide), Gabatril (Tiagabine) and Inovelon (Rufinamide), which isn't available in the U.S. Since Lyrica is about the only thing that has worked for her, it would be nice to find a medication that has a similar mechanism of action.

1 comment:

Tara said...

Sorry Depakote didn't work for Mira. We tried to lower Aidan's Lyrica because he was becoming a ZOMBIE on 100mg a day, but the head drops returned. Now we have him back up and have increased his ratio with his Ketocal and hopefully that will do the trick. Keep me posted on what you try next since Aidan and Mira are in similiar situations when it comes to meds.